Job Information
Amgen Associate Scientist, Predictive Biology (14 Month Contract) in Burnaby, British Columbia
HOW MIGHT YOU DEFY IMAGINATION?
You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.
Role: Associate Scientist – Predictive Biology (14 month contract)
Reports to: Sr. Principal Scientist
Level: 4B
Location: Burnaby, BC
Live
What you will do
Let’s do this. Let’s change the world. We have an opening for an Associate Scientist in our Predictive Biology group, located in beautiful British Columbia, Canada. Our team focuses on developing and implementing novel innovations that address some of the most pressing problems in bringing novel therapeutics antibodies to patients.
In this vital role you will focus on the development of an in vitro platform composed of patient derived cell lines and organoids that will allow us to better predict efficacy and safety liabilities in our Biologic drugs. Specifically, this role will involve the development, optimization, and maintenance of patient derived organoids (PDO) which will be used for screening the therapeutic potential of antibody-drug conjugates (ADC) candidates. Additionally, you will be asked to expand our capabilities through the creation of novel protocols for high content image-based screening for ADC using organoids.
Responsibilities include but are not limited to:
Design, implement, and troubleshoot experiments to develop and improve PDO cultures from different tissues in both normal and diseased states.
Perform expansion of cell and organoid cultures including biobanking
Characterize organoids by multi-color flow cytometry, multiplex cytokine secretion assays, confocal microscopy, RNASeq or related techniques.
Genetic engineering of PDO for target validation
Perform bioassay screens for evaluation of therapeutic antibody candidates
Maintain clear records of experimental details in a laboratory notebook.
Win
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an individual with these qualifications.
Basic Qualifications:
Master’s degree and 1 year of related experience
Or
Bachelor’s degree and 3 years of related experience
Preferred Qualifications:
Experience with primary cell and organoid cultures is desired
Familiarity with confocal and/or high-content imaging platforms such as the Opera Phenix and corresponding image analysis software
Experience in bioassay development for drug screening and delineating mechanisms of action, particularly with respect to ADCs and other biologics
Experience in standard immunoassay techniques such as flow cytometry, cytokine secretion, viability assays, etc.
Demonstrated ability to work both independently and collaboratively in a team-oriented environment.
Ability to multi-task and stay organized in the face of shifting priorities.
Thrive
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
The salary range for this position in Canada is $84,000 - $120,000 CAD.
In addition to the base salary, Amgen offers the following to staff on contract:
An option of a comprehensive health benefits package, or an additional 10% “in lieu of benefits” allowance
Award-winning time-off plans and annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possible
Robust Learning and Development opportunities
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com