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Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC ® Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC ® targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: vepdegestrant for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer; ARV-102 for the treatment of patients with neurodegenerative disorders, and ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas.

In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC ® androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.

#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it –  learn more about life at Arvinas and what employees have to say .

For more information, please visit www.arvinas.com .

Position Summary

This position will be laboratory-based, working directly with a team of scientists within the Immuno-Oncology Group. The individual will gain first-hand experience in cancer drug discovery by helping to execute and analyze immune cell biology experiments. Within a fast-paced, collaborative environment the individual will be expected to learn quickly and make meaningfully contributions to the progression of potential cancer therapeutics.

This will be a full-time, on-site position located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Training on various immune-based assays which will then be performed and analyzed with minimal supervision

• Learning methods for assessing protein levels and expression in various bioassays from in vitro cultures including: MSD-based ELISA, qPCR (QuantStudio 6 platform), flow cytometry (BD Fortessa, DIVA, FlowJo), protein quantification via western blot (traditional and higher throughput Jess platform)

• Training and performing immunological cellular functional assays including primary human T cell activation, primary human naïve T cell purification, cytokine production assessment, naïve T cell differentiation/polarization

• Communicating experimental data to team and group members, writing up experimental procedures, and providing thorough documentation using an electronic lab notebook

• Building productive networking relationships

• Demonstrating excellent organizational and prioritization skills

Qualifications

• Prior experience with cell culture is required (preferably immune cells including primary human peripheral blood mononuclear cells, murine splenocytes, naïve human CD4 + T cells)

• Prior experience with BD FACs DIVA platform, FlowJo analysis, cytokine ELISA, and qPCR methods is highly desirable

• Proficient understanding of cell and molecular biology and immunology

• Capable of independent work, through record keeping

• Open to constructive feedback, eager to lean, freely ask questions, works well in a collaborative environment

• Proficiency with Microsoft Office Suite

• Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship.

• The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Education

• Preference to experienced Masters or Ph.D. level students in immunology, pharmacology, cell biology, or relevant discipline

• Completed advanced coursework in cell biology and/or immunology highly desirable

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer